Our Culture of Innovation

Vertex innovation programs bring together the brightest minds to strike at the core of serious diseases.

About Our Programs

Innovation at Vertex is driven by a single purpose: to transform lives. We have an entire department dedicated to innovation (VIER, or Vertex Innovation and External Research) and have developed both internal and external programs so our culture of innovation can grow even further. These innovation programs are focused on four strategic objectives that support our overall goal of making Vertex a phenomenal place to innovate.

  • Generate and implement new ideas: Through innovation tournaments, hackathons and partnerships, we solve mission critical challenges to bring new medicines to patients.
  • Support all functions as innovators: We partner with people and departments in all areas of the business to innovate through challenges.
  • Create new connections: We host brilliant speakers to share their work on a variety of topics. These diverse perspectives inspire and motivate us to think about new ways to address challenges.
  • Nurture creative people: We believe innovation is a trained skill. We teach our colleagues the science of innovation and support them throughout their creative process.

Our core innovation programs include the Vertex Fellows program, Vertex Opportunities for Intrapreneurship and Corporate Evolution (VOICE) and the Science and Medicine seminar series.

The Vertex Fellows program is a unique, one-year opportunity for outstanding early career scientists and physicians to join Vertex project teams and help advance real drug discovery programs. In addition to hands-on experience, Fellows receive training on the drug discovery process, mentorship from senior leaders and exposure to many different business areas. The program is designed to augment, rather than replace, a traditional postdoctoral, residency or business school experience. David Altshuler, Executive Vice President, Global Research and Chief Scientific Officer, directs the program in collaboration with many leaders across the company.

“The point of the Fellows Program is to make sure that we remain fresh, we bring in new people, new ideas, and also that we give back.”

David Altshuler, M.D., Ph.D.
Executive Vice President, Global Research and Chief Scientific Officer

What we look for in a Fellow:

  • Experience conducting and leading breakthrough research
  • Entrepreneurial spirit for solving challenging problems with innovative solutions
  • Thirst for knowledge and the desire to better understand how drugs are developed
  • Completion of a Ph.D., an M.D., or a joint degree within 5 years of starting the fellowship

Fellows Program Timeline:

We are now accepting applications for the 2022-2023 Vertex Fellows Program. Please submit your CV and a cover letter via one of the links below for the site location you’re most interested in. Within the application, you will be able to note location preferences.

Apply to Boston Apply to San Diego Apply to Oxford, UK


Important Dates:

  • Application deadline: January 14, 2022
  • Candidate interviews: March 2022 (Note: if selected for interview you will be asked for a Letter of Recommendation from your advisor)
  • Fellowship begins: Between July and September 2022, on a mutually agreed upon date
Hear From Our Fellows:


Each year, the Vertex Physician Investigator Career Development Program brings together exceptional early career physician-scientists for a two-year, immersive, rotation-based, biotech training program. The program provides participants with a broad understanding of the drug development process and enables future leadership opportunities throughout the organization. Program participants join Vertex as full-time employees and receive didactic training and engage in experiential learning about the science and medicine of drug discovery.


Why be a Vertex Physician Investigator?

  • Full-time employment with a leading innovative biotech company
  • Help patients by contributing to the development of transformative medicines
  • Learn about drug discovery to help inform future work
  • Advance a scientific idea rapidly in a team-based environment
  • Receive mentorship from scientific, medical and business leaders at Vertex
  • Accelerate career growth

Who is eligible?

  • Early career MD/PhDs or MDs with a proven research track record with expressed interest in biopharmaceutical research
  • Less than 5 years since completion of training
  • Evidence of scholarly distinction, investigative work
  • Early career faculty looking to move to industry

Applications for the 2022 class of Vertex Physician Investigators are now being accepted through January 14, 2022. Interested applicants can submit their CV/resume and a 1-page cover letter here. Candidates will be reviewed and accepted on a rolling basis. For more information, please email VPI@vrtx.com.


VOICE is an internal global innovation tournament that empowers all employees to develop ideas inspired by game-changing science or business challenges. Employees who have their ideas selected go on to build cross-functional teams, develop refined proposals and execute their winning plans. VOICE injects Vertex’s culture with an entrepreneurial spirit by encouraging employees to become change makers who can contribute to the direction of the company and help advance our goal of discovering cures for serious diseases.

Since the program began in 2015, dozens of ideas have been implemented, including:

  • Initiating a major research program in a new disease 
  • Developing multiple exploratory research projects 
  • Building a 3D printing lab
  • Designing a mobile app to help Vertexians find one another 
  • Creating a commuter bus program to reduce traffic congestion in Boston’s Seaport District

“It's amazing to see the innovation that happens - it just blossoms on its own.”

Marcy Bennett
CF Patient Services Associate Director & VOICE Steering Committee Member

“VOICE gives employees a way to get involved in something that wouldn't be part of their normal day job - something that is outside of the realm of maybe anything they've ever done before, but they now have permission and the opportunity to really throw themselves into it.”

Pat Spain
Quality Systems Director & VOICE Participant
See VOICE in Action

The Science and Medicine speaker series connects our employees with cutting-edge leaders across the industry. We look for thought-provoking speakers and ideas that challenge us to think about scientific problems in new ways. In this way, we encourage our employees to remain lifelong learners who bring fresh ideas and perspectives to the table.

Recent speakers include Atul Gawande (Brigham and Women's), Aviv Regev (Broad, MIT), Kay Davies (Oxford), Aravinda Chakravarti (Hopkins), Vamsi Mootha (MGH), Jeffrey Kopp (NIH), Kit Parker (Harvard), Rick Lifton (Rockefeller), Mahzarin Banaji (Harvard), Vijay Pande (Stanford) and George Daley (Harvard).