Vertex at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
Vertex will present data on INCIVEK® (telaprevir) tablets, approved for the treatment of genotype 1 hepatitis C in adults with compensated liver disease, and two of its hepatitis C medicines in development, the uridine nucleotide analog pro-drug ALS-2200 (VX-135) and the non-nucleoside polymerase inhibitor VX-222 at the 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston, November 9 to 13, 2012.
The titles of the 11 accepted abstracts are included below. The complete abstracts are now available through the AASLD website at www.aasld.org.
Media Contacts 617-444-6992
Dawn Kalmar
Erin Emlock
Zachry Barber
Investor Relations Contacts
Michael Partridge (617) 444-6108
Kelly Lewis (617) 444-7530
ALS-2200 (VX-135) Presentations
1. “ALS-2200, a Novel Once-Daily Nucleotide HCV Polymerase Inhibitor, Demonstrates Potent Antiviral Activity over 7 Days in Treatment-Naïve Genotype 1 (GT1) Patients.” November 11, 2012, 5:00 p.m. EST.
Oral Presentation #86
2. “Preclinical Characterization of ALS-2200, a Potent Nucleotide Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.” November 13, 2012, 8:00 a.m. – 12:00 p.m. EST. Poster Presentation #1882
“Analysis of ALS-2200, a Novel Potent Nucleotide Analog, Combination Drug Interactions in the Hepatitis C Virus (HCV) Subgenomic Replicon System.” November 13, 2012, 8:00 a.m. – 12:00 p.m. EST. Poster Presentation #1887
INCIVEK (telaprevir) Presentations
1. “Telaprevir in Combination with Peginterferon Alfa-2a/Ribavirin in HCV/HIV Co-infected Patients: SVR24 Final Study Results.” November 11, 2012, 4:15 p.m. EST. Oral Presentation #54
2. “Evaluation of Liver and Plasma HCV RNA Kinetics and Telaprevir Levels in Genotype 1 HCV Patients Treated with Telaprevir using Serial Fine Needle Aspirates.” November 13, 2012, 9:00 a.m. EST. Oral Presentation #215
3. “The Safety of Telaprevir in the Absence of Interferon and/or Ribavirin: Analysis of On-Treatment Data from the ZENITH Trial.” November 11, 2012, 8:00 a.m. – 5:30 p.m. EST. Poster Presentation #786
4. “Factors Predictive of Anemia Development in Treatment-Experienced Patients Receiving Telaprevir (TVR) Plus Peginterferon/Ribavirin (PR) in the REALIZE Trial.” November 11, 2012, 8:00 a.m. – 5:30 p.m. EST. Poster Presentation #771
5. "Rate of Disappearance of Telaprevir Resistant Variants Using Clonal and Population Sequence Data from Phase 3 Studies.” November 11, 2012, 8:00 p.m. – 5:30 p.m. EST. Poster Presentation #756
6. “Deep Sequencing of the HCV NS3/4A Region Confirms Low Prevalence of the Telaprevir-Resistant Variants Both at Baseline and End of Study.” November 11, 2012, 8:00 p.m. – 5:30 p.m. EST. Poster Presentation #1091
VX-222 Presentations
1. “VX-222, Telaprevir and Ribavirin in Treatment-Naïve Patients with Genotype 1 Chronic Hepatitis C: Results of the ZENITH Study Interferon-Free Regimen.” November 13, 2012, 11:15 a.m. EST. Oral Presentation #231
“Effect of Hepatic Impairment on the Pharmacokinetics of VX-222: Results From a Multicenter Phase 1 Study.” November 13, 2012, 8:00 a.m. – 12:00 p.m. EST. Poster Presentation #1880